Hypericum perforatum
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Significant interaction risk: induces liver enzymes (CYP3A4) that speed up metabolism of many medications, including hormonal birth control (can reduce effectiveness), blood thinners like warfarin, immunosuppressants (organ transplant rejection has occurred), and some HIV and cancer medications. Combined with SSRIs, SNRIs, or MAOIs, it carries a risk of serotonin syndrome, a potentially life-threatening reaction. Do not combine with any prescription medication without a pharmacist or physician's review. Also increases sun sensitivity.
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Plant description, traditional uses, preparation notes, related herbs, and full sourcing for St. John’s Wort — plus every herb in the collection — are available to Full Herbarium members.
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